Author

Sean P Maroney

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Open access Aug 2026

Mesenchymal Stem Cell Secretome Mitigates Inflammatory Endothelial Dysfunction.

BACKGROUND Endothelial cells (EC) dysfunction and barrier disruption are central drivers of inflammatory lung injury and adverse outcomes, yet targeted therapies remain lacking. We tested the hypothesis that a mesenchymal stem cell (MSC)-derived secretome can directly preserve EC function under inflammatory stress. We...

Marissa D Pokharel, Baron K Osborn, Anthony J. Saviola et al. · Shock · 0 citations

Open access Jul 2026

N-terminal processing unlocks global dynamics for substrate engagement in Spl proteases

Dynamic allostery is established as the mechanism of N-terminal activation in this subclass of serine proteases in a pathogenic methicillin-resistant S. aureus strain and mutational perturbation of this dynamic network modulates substrate engagement and catalytic activity in a manner consistent with dynamic control of...

Eunjeong Lee, J. Redzic, Samrat Sarkar et al. · Science Advances · 0 citations

Open access Aug 2026

Structural and Functional Interrogation of Active Streptococcus pneumoniae Sortase A

Sortase A (SrtA) enzymes covalently anchor surface proteins to Gram-positive bacterial cell walls, promoting colonization and virulence. In Streptococcus pneumoniae, previous studies identified both a domain-swapped dimer and an active refolded monomer, but the active enzyme has not been characterized at the structural...

Eunjeong Lee, Blaine H. Gordon, J. Redzic et al. · Biomolecules · 0 citations