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Sebastian N. Roemer-Cassiano

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Open access Oct 2026

Network‐dependent remote effects and local tau burden jointly shape neuronal dysfunction in Alzheimer's disease

Abstract BACKGROUND Tau pathology in Alzheimer's disease (AD) propagates along the brain's connectome, yet the mechanisms by which tau drives neuronal dysfunction remain unclear. We hypothesized that dysfunction primarily emerges in regions close to tau‐harboring epicenters. METHODS One hundred thirty‐one amyloid‐posit...

Lukas Frontzkowski, Sebastian N. Roemer-Cassiano, Johannes S. Gnörich et al. · Alzheimer's & Dementia · 0 citations

Preprint Aug 2026

Activity-dependent epidemic spreading on multiscale brain networks predicts Alzheimer's disease progression

The results connect epidemic theory to neurodegeneration, implicate neuronal activity as a driver of Alzheimer's disease progression, and motivate activity-modulating therapies to slow or prevent pathological spread are connected.

Christoffer G. Alexandersen, Suman S. Kulkarni, Jessica T. Davis et al. · 1 citation

Open access Sep 2026

Dynamic [18F]PI-2620 recording facilitates prediction of β-amyloid positivity and simultaneous staging of tau and neurodegeneration

Dynamic [18F]PI-2620 PET imaging facilitates assessment of the β-amyloid status and regional staging of tau and neurodegeneration during a single acquisition, and may reduce radiation exposure, streamline diagnostic workflows, and facilitate personalized disease profiling.

Johannes S. Gnörich, J. Kusche-Palenga, Agnes Kling et al. · Molecular Neurodegeneration · 0 citations

Open access Aug 2026

Mesoscale medial temporal lobe connectivity patterns relate to tau pathology and memory in older adults

Differential associations of age and AD pathology with mesoscale MTL-connectivity patterns show differential associations of age and AD pathology with mesoscale MTL-connectivity patterns, which may support memory function in the short term while contributing to subsequent memory decline.

Larissa Fischer, N. Vockert, Joseph Höpker Fernandes et al. · bioRxiv · 0 citations