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Seby Edassery

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Open access Sep 2026

PERM1 Gene Therapy Prevents Pressure Overload-induced Heart Failure Through a Sarcomere-Mitochondria Energetic Microdomain

Heart failure with reduced ejection fraction (HFrEF) remains a major cause of morbidity and mortality worldwide, characterized by impaired contractile function and mitochondrial dysfunction, yet therapies that simultaneously restore cardiac energetics and mechanical performance remain limited. Here, we show that adeno-...

Karthi Sreedevi, A. Doku, Alexey V. Zaitsev et al. · 0 citations
Open access Jul 2026

Contractility Drives Cardiomyocyte Maturation and the Response to Nanopatterns

Calcium-activated contractility is dispensable for sarcomerogenesis but critical for cardiomyocyte maturation, and mass spectrometry datasets cataloging iPSC-CM maturation represent a useful resource for the cardiovascular research community.

Laura A. Sherer, Abigail Nagle, M. Papadaki et al. · 0 citations

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