Open access
Aug 2026
Nano-flow intracalvariosseous infusion enables skull-to-brain delivery of BBB-impermeable molecular and nanoscale agents in mice and rabbits
Rationale The blood–brain barrier (BBB) remains a major obstacle to the delivery of therapeutics for central nervous system (CNS) diseases. Although several BBB-penetrating or BBB-bypassing strategies have been investigated, there remains a need for sustained, controllable delivery routes that can support prolonged CNS...
Ji-Hee Kang, O. H. Lee, Min Suk Shim et al.
· Theranostics · 0 citations