Dexmedetomidine attenuates methamphetamine-induced hyperthermia and hyperlocomotion in male rats and modulates monoamine dynamics in the anterior hypothalamus.
RATIONALE Methamphetamine (METH) intoxication is associated with serious complications, including hyperthermia and agitation, which are major contributors to morbidity and mortality. Currently, no established pharmacological interventions are available for these conditions. OBJECTIVES To evaluate the effects of dexme...