Author

Seishi Ogawa

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Open access Aug 2026

OA04.7. Development of a Prediction Model for Esophageal Squamous Cell Carcinoma Using Somatic Mosaicism in the Buccal Mucosa

Esophageal Cancer: Esophageal Carcinogenesis The oral cavity, pharynx, and esophagus are covered by anatomically contiguous squamous epithelium, and alcohol consumption and smoking are well-established common cancer risk factors for the three organs. The aim of this study is to analyze somatic mosai...

Akira Yokoyama, Koichi Watanabe, Y. Inoue et al. · Diseases of the esophagus · 0 citations

Open access Aug 2026

Geneformer-guided multiomics integration identifies Pbx1 as a network hub of hematopoietic stem cell aging

In insight into HSC aging, Pbx1 is identified as a key regulator of these age-related transcriptional and differentiation changes and may inform approaches to modulate age-associated HSC dysfunction.

Hiroshi Kobayashi, Shintaro Watanuki, Yusuke Shiozawa et al. · Science Advances · 0 citations

Aug 2026

SLF2 and SMC5 dysfunction drives HSC aging and predisposes to MDS, defining a new inherited bone marrow failure syndrome.

It is demonstrated that SLF2 and SMC5 dysfunction drives premature HSC aging, bone marrow failure, and predisposition to MDS, revealing Atelis Syndrome as a previously unrecognized IBMFS.

Sho Shibata, K. Chonabayashi, Hirofumi Nakamura et al. · Leukemia · 1 citation