Author

Seline Roose

2 papers indexed here

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Open access Oct 2026

Charge-Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti-Cancer Treatment.

Inorganic anticancer drugs such as cisplatin remain central to chemotherapy but are limited by poor tumor selectivity, rapid clearance, and off-target toxicity. We recently developed cationic Pt2L4 nanocages with 12-fold higher anticancer activity than cisplatin in PC-3M-Pro4 cells in vitro, but their positive charge c...

Renzo A. Knol, Bo-Chuan Hu, E. Bobylev et al. · Advances in Materials · 0 citations

Open access Sep 2026

Remote Residue Substitution and Macrocyclization Preorganize a β‐Hairpin Peptide and Enhance β‐Catenin Binding

Peptide‐based inhibitors are promising tools to target challenging protein interfaces, yet improving their affinity and drug‐like properties is still a major hurdle. This holds particularly true for β‐sheet motifs with only limited strategies available to robustly stabilize their conformation. Previously, we reported l...

Michael H. N. Meulendijks, Yun Li, Frederik J. Steiner et al. · ChemistryEurope · 0 citations