Author

Sen-Fang Sui

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Open access Aug 2026

DYNAMIC CONFORMATIONS IN THE ACTIVATION OF PINK1 KINASE

Under mitochondrial stress, the mitochondrial kinase PINK1 is activated to phosphorylate ubiquitin, which in turn recruits the E3 ligase Parkin, thereby initiating clearance of damaged mitochondria. Dysregulation of the PINK1–Parkin signaling pathway is associated with early- onset autosomal recessive Parkinson’s disea...

Huiqin Xu, Xin-Yang Liu, Yan Jiang et al. · bioRxiv · 0 citations

Activation of Degp Chaperone-Protease Via Formation of Large Activation of Degp Chaperone-Protease Via Formation of Large Cage-Like Oligomers Upon Binding To Substrate Proteins Cage-Like Oligomers Upon Binding To Substrate Proteins

A mechanism for DegP to activate both functions via formation of large cage-like 12-and 24-mers after binding to substrate proteins is reported, which eliminates the inhibitory effects of the PDZ2 domain.

Jiansen Jiang, Xue-Feng Zhang, Yong Chen et al. · 0 citations

Open access Aug 2026

MOLECULAR BASIS FOR PINK1 MATURATION

A general mechanism for PINK1 recognition by the HSP90α/CDC37/FKBP51 chaperone complex is revealed and a potential approach for upregulating PINK1 activity, which is impaired in PD is suggested.

Junrong Xue, Huiqin Xu, Yanfeng Zhang et al. · bioRxiv · 0 citations