Author

Sen Zhang

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Review Open access Aug 2026

Multicellular immunosuppressive networks in microsatellite-stable colorectal cancer: CD8+ T cell exclusion, dysfunction, exhaustion, and therapeutic implications

Microsatellite-stable (MSS) colorectal cancer (CRC), comprising ~85–90% of cases, remains almost universally refractory to PD-1/PD-L1 monotherapy (objective response rate 5–10%), in stark contrast to the marked efficacy of immune checkpoint inhibitors (ICIs) in microsatellite-instability-high (MSI-H) disease. Here we s...

Zhi-Yuan Xia, Hai-Ning Chen, Ye-Fu Shen et al. · Frontiers in Immunology · 0 citations

Review Open access Aug 2026

Metabolite-driven protein modifications in immune signaling: from established principles to emerging pyruvylation

The conceptual framework of metabolite-driven protein modifications is summarized, established marks are compared, and remaining questions surrounding pyruvylation chemistry, enzyme and substrate specificity, reader mechanisms, compartmentalization, detection strategies, physiological relevance, and potential immunopha...

Zi-Ye Zhang, Ming-Ze Xu, Sen Zhang et al. · Frontiers in Immunology · 0 citations