Author

Senem Akkoç

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Open access Sep 2026

Cytotoxicity of Betaine in 4T1 and L929 Cells: In Silico ADMET Profiling

Betaine, a naturally occurring zwitterion, was evaluated for its anticancer potential against murine 4T1 breast cancer cells and non-cancerous L929 fibroblast cells. Cells were treated with various concentrations for 48 hours, and viability was assessed using the MTT assay. Betaine showed weak, dose-dependent cytotoxic...

E. Akgün, Büşra Gülbenli Türkoğlu, Yasemin Sunucu-Karafakıoğlu et al. · Celal Bayar Universitesi Fen... · 0 citations

Aug 2026

Synthesis of Novel 4,6‐Dimethoxyindole‐Based Hydrazones Derived From 2,4‐Dimethoxybenzaldehyde: Design, Cytotoxic Activity, Molecular Docking, and ADME‐Tox Studies

In silico ADME‐toxicity analyses predicted acceptable physicochemical and pharmacokinetic properties, supporting the potential of these derivatives as promising anticancer candidates.

Reşit Çakmak, Eyüp Başaran, Senem Akkoç et al. · ChemistrySelect · 0 citations

Open access Aug 2026

Comprehensive Investigation of Benzimidazolium Derivatives Through Synthesis, Characterization, Cytotoxicity Activity, Immunocytochemistry, and ADME and Toxicity Analyses

The results indicated that the compounds possess high lipophilicity but show limited bioavailability due to low solubility and none of the compounds were predicted to cross the blood–brain barrier, which limits their potential for direct effects on the central nervous system.

G. Dilek, Senem Akkoç · ChemistryOpen · 0 citations