Senthilkumar Sankararaman

Hemodynamic-Guided Nutrition Support in Pediatric Congenital Heart Disease

Nephrolithiasis in Cystic Fibrosis: A Gastrointestinal Perspective on Mechanisms and Management.

In the current era of cystic fibrosis (CF) transmembrane conductance regulator (CFTR)-directed therapies (modulators), people with CF have significant improvement in pulmonary disease burden and overall survival. Extrapulmonary complications, including those affecting the gastrointestinal and renal systems, are gaining...

Overview of Non-Cirrhotic Portal Hypertension in Pediatric Patients

Non-cirrhotic portal hypertension (NCPHT) is defined as portal hypertension (PHT) occurring in the absence of cirrhosis. Major etiological causes of NCPHT include immunological disorders, chronic infections, exposure to medications or toxins, prothrombotic conditions, and several genetic syndromes, highlighting that NC...

Feeding or Failing? Rethinking Nutrition Therapy in Pediatric Critical Care

Malnutrition, whether pre-existing or acquired in the ICU, is common in critically ill children. This narrative review synthesizes current evidence on nutritional assessment and therapy, highlighting how illness phase, underlying disease, and medical interventions influence energy expenditure and nutrient requirements....

Vitamin A Status in Cystic Fibrosis in the Current Era of CFTR-Directed Therapies

People with aCFLD, renal insufficiency, post-lung transplantation, and pregnancy are prone to vitamin A toxicity, and CF clinicians should be proactive in evaluating these abnormalities and proficient in managing both deficiency and toxicity, as both these conditions can be associated with adverse outcomes.