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Seok Keun Cho

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Open access Sep 2026

PNPLA3 Is Associated With Hepatocellular Carcinoma, While a Five-Variant Polygenic Risk Score Shows Limited Discrimination in Korean Patients With MASLD.

BACKGROUND/AIMS Genetic variants in PNPLA3, TM6SF2, MBOAT7, GCKR, and HSD17B13 have been associated with MASLD progression and hepatocellular carcinoma (HCC). We evaluated their associations with prevalent HCC and the performance of a five-variant polygenic risk score (PRS-5) in Korean patients with MASLD. METHODS A...

Jaejun Lee, J. Cha, Hee Sun Cho et al. · 0 citations

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