Open access
Aug 2026
CA-IV-directed small-molecule shuttle enables targeted brain delivery of biologics.
The blood-brain barrier (BBB) presents a challenge for central nervous system (CNS) therapies. Receptor-mediated transcytosis offers a solution, but existing receptor targets are ubiquitous across CNS and peripheral tissues, causing unintended exposure. We identified carbonic anhydrase IV (CA-IV) as a brain-enriched re...
Xiaozhe Ding, Xinhong Chen, Philip Boehm et al.
· Nature Chemical Biology · 0 citations