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Author

Serina Easmin

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Review Sep 2026

Penpulimab: A Next-Generation Fc-Engineered PD-1 Inhibitor in Cancer Immunotherapy.

Penpulimab (AK105) is a novel Fc-engineered, humanised IgG₁ monoclonal antibody targeting programmed cell death protein-1 (PD-1). Unlike conventional PD-1 inhibitors, penpulimab has been designed to eliminate Fcγ receptor and complement C1q binding, thereby reducing Fc-mediated effector functions while maintaining anti...

Serina Easmin, Sangita Palai, Sudip Saha et al. · 0 citations

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