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Author

Seth M. Pollack

2 papers indexed here

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Open access Oct 2026

Attenuating NKG2D stimulation reshapes intratumoral NK cell functional state to enhance persistence and anti-tumor efficacy.

NK cell-based therapies for solid tumors are limited by poor persistence and progressive functional impairment. Here, we investigated how the strength of NKG2D stimulation shapes NK cell fate and therapeutic efficacy. Using B10G5, a MICA/B-targeting partial agonist antibody that attenuates NKG2D stimulation, we show th...

Si-Zhe Liu, Ryan J. Brown, Payal Dhar et al. · 0 citations
Review Open access Oct 2026

Nivolumab and Cabozantinib in People with HIV and Advanced Solid Tumors: A Pilot Trial and Systematic Review.

BACKGROUND People living with HIV (PWH) are underrepresented in immune checkpoint inhibitor (ICI) and targeted therapy trials, despite a growing burden of malignancies. Cabozantinib may remodel the tumor microenvironment by reducing immunosuppressive myeloid populations and enhancing cytotoxic T-cell infiltration, ther...

Hai-Ying Cheng, Ece Cali, Mumtu Lalla et al. · 0 citations

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