Open access
Jul 2026
SUMOylation modulates glucocorticoid-induced muscle toxicity in cell and mouse models.
Prolonged glucocorticoid (GC) exposure is a clinically relevant cause of skeletal muscle atrophy through activation of glucocorticoid receptor (GR)-dependent catabolic transcriptional programs, including those mediated by Krüppel-like factor 15 (KLF15). However, the post-translational regulatory mechanisms that modulat...
Ahyoung Lee, Y. Jeong, Hayeong Kwon et al.
· Scientific Reports · 0 citations