Open access
Oct 2026
SHMT2 Suppression Disrupts Redox Homeostasis and Induces Ferroptosis Through the GSH–GPX4 Axis in Head and Neck Cancer
Head and neck squamous cell carcinoma (HNSCC) remains one of the most prevalent and aggressive malignancies worldwide. Serine hydroxymethyltransferase 2 (SHMT2), a key enzyme in one-carbon metabolism, is essential for tumor cell proliferation and redox homeostasis. Whether SHMT2 regulates ferroptosis, an iron-dependent...
Shan Shen, M. Lim, Si-Cong Zheng et al.
· Antioxidants · 0 citations