Author

Seyed Pouria Motevalian

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Open access Aug 2026

Impact of single-use bioreactor bag materials on Spodoptera frugiperda cell expansion for recombinant adeno-associated virus manufacturing.

Recombinant adeno-associated virus production for gene therapy applications commonly relies on the Spodoptera frugiperda 9 (Sf9) baculovirus infection platform. The process encompasses cell expansion from flasks through intermediate-scale bioreactors to large-scale production. A critical challenge in this process is su...

Min Tae Park, Seyed Pouria Motevalian · Biotechnology progress (Prin... · 0 citations

Open access Jul 2026

High-throughput development and scale-up of recombinant adeno-associated virus 5 anion-exchange chromatography for high-purity capsid separation.

A high-throughput, ultra-scale-down platform using 200 μL RoboColumns™ was established to enable rapid screening of salt systems, additives, and operating conditions with minimal material requirements, and the identification of a magnesium-only system that improved both enrichment and recovery.

Kevin Vera, Ivan Gajic, Praveen Kusumanchi et al. · Biotechnology progress (Prin... · 0 citations

Open access Jul 2026

rAAV production cost analysis: Indication-specific cost per dose and reduction strategies.

Recombinant adeno-associated virus (rAAV) vectors underpin many approved and late-stage gene therapies, yet manufacturing costs remain a major driver of therapy price. Here, we present the first comprehensive, platform-resolved cost analysis of rAAV production across three industrially relevant suspension platforms: tr...

Min Tae Park, Dan Matuszek, A. Andaluz et al. · Gene Therapy · 0 citations