Seyedeh Zohreh Mirjalili

Novel diazene-tri(phenoxy-1,2,3-triazole-acetamide) derivatives as potent α-glucosidase inhibitors: synthesis, biological evaluation, and in silico studies

Kinetic enzyme assays revealed that compound 9f acts as a competitive inhibitor of α-glucosidase, competing with the natural substrate for binding to the active site, with a Ki value of 100 nM, and pharmacokinetic predictions showed that compound 9f exhibits a bioavailability radar and drug-likeness profile similar to...