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Author

Şeyma Ateşoğlu

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Aug 2026

Short and efficient synthesis of the natural triterpenoids α- and β-amyrins with detailed in silico screening and in vitro anticancer evaluation against breast and prostate cancer cells.

α- and β-Amyrins are biologically important pentacyclic triterpenoids that occur at low levels in natural sources, making their isolation difficult. In this study, a simple and cost-effective semisynthetic route was developed to obtain α- and β-amyrins from ursolic acid and oleanolic acid in three steps, and the produc...

Halil Şenol, Salih Tuncay, Şeyma Ateşoğlu et al. · 0 citations
Aug 2026

Rational design of thiazolidine-2,4-dione-integrated combretastatin A-4 analogues as potent and selective tubulin-targeting agents for triple-negative breast cancer.

The present study identifies compounds 2 and 3 as promising lead candidate that combines potent and selective antiproliferative activity, strong tubulin polymerization inhibition, and favorable binding characteristics compared with paclitaxel.

F. S. Tokalı, Şeyma Ateşoğlu, Pelin Tokalı et al. · 1 citation

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