An integrated immunoinformatics and experimental pipeline identifies an LCL-scaffolded OmpA loop 3 construct as a protective vaccine candidate against Acinetobacter baumannii.
Acinetobacter baumannii has emerged as a critical nosocomial pathogen due to its extensive antimicrobial resistance and limited treatment options, highlighting the urgent need for effective vaccines. In this study, we developed and evaluated a rationally engineered epitope-based vaccine targeting extracellular loop 3 o...