Author

Shahrzad Ashena

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Open access Sep 2026

Association of Three HIF‐1α Genotypes With Susceptibility and Severity of Chronic Kidney Disease

ABSTRACT Hypoxic signaling is a critical factor in the pathogenesis of Chronic Kidney Disease (CKD). Hypoxia‐Inducible Factor 1 (HIF‐1) is a transcription factor that is highly expressed in the kidney and is associated with renal tubular hypoxic adaptation. Variation in the HIF‐1α subunit gene has been associated with...

Hanifa Aktar, Shahrzad Ashena, Mohammad Sanaei Ardekani et al. · Clinical and Translational S... · 0 citations

Open access Oct 2026

Implementation of Rapid CYP2C19 Genotyping to Guide Antiplatelet Therapy for Secondary Prevention of Ischemic Stroke and Transient Ischemic Attack.

Clopidogrel is first-line for secondary stroke prevention, but its effectiveness is affected by CYP2C19 genetic variation. An American Heart Association (AHA) scientific statement concluded that CYP2C19-guided P2Y12 inhibitor (P2Y12i) therapy is evidence-supported, though real-world application depends on implementatio...

D. M. Smith, Pamela Ramos Ramos, Shahrzad Ashena et al. · Clinical pharmacology and th... · 0 citations