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Author

Shalini Sharma

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Open access Aug 2026

Design, synthesis, and evaluation of pyrano[3,2-c]coumarin derivatives for simultaneous targeting of amyloid-β42 and acetylcholinesterase in transgenic AD model of Drosophila

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder involving amyloid-β (Aβ) aggregation, cholinergic dysfunction, oxidative stress, mitochondrial impairment, and progressive neuronal loss. Consequently, the development of multi-target-directed ligands (MTDLs) capable of modulating multiple patholog...

Saurabh Sharma, Shalini Sharma, Vaishali Raghuvanshi et al. · 0 citations
Open access Jul 2026

Network pharmacology and in silico analysis of Azadirachta indica phytoconstituents reveal potential hepatoprotective targets and mechanisms.

This integrative computational network pharmacology analysis provides novel insights into the pathogenesis of liver diseases (HT/HI) and identifies potential therapeutic targets, exploring biomarkers for future experimental validation and clinical translation.

M. Kumari, A. Srivastava, Subhashini et al. · 0 citations

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