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Author

Shambhu Joshi

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Open access Oct 2026

NE52-QQ57 attenuates post-ischemia protein phosphorylation in the mouse brain

Introduction Cerebral ischemia induces a reduction in brain pH. GPR4, a proton-sensing G protein-coupled receptor is highly expressed in vascular endothelial cells. Pharmacological inhibition of GPR4 with NE52-QQ57 (NEQQ) reduces ischemia-induced blood-brain barrier (BBB) disruption and brain injury. To facilitate targ...

Shambhu Joshi, You-Fang Zhou, Xiang-Ming Zha · 0 citations

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