Author

Shamim Pourbahrighesmat

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Review Open access Sep 2026

Interkingdom microbiome physiology in colorectal cancer: barrier dysfunction, immune-metabolic signaling, and therapeutic resistance

Colorectal cancer develops within a physiologically altered intestinal ecosystem. Epithelial barrier disruption, chronic inflammatory signaling, immune remodeling, and metabolic rewiring reshape host-microbial interactions in this niche. Although most colorectal cancer microbiome reviews have emphasized bacterial taxa,...

Shamim Pourbahrighesmat, Alireza Tojjari, G. Laliotis et al. · Frontiers in Physiology · 0 citations

Review Sep 2026

Biomarker-Guided Treatment Selection in Metastatic Colorectal Cancer: A Critical Review of Established and Emerging Therapies.

This structured narrative review separately examines mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) and microsatellite-stable/mismatch repair-proficient (MSS/pMMR) disease and distinguish established treatments from investigational strategies and identify the remaining evidence gaps.

Alireza Tojjari, Shamim Pourbahrighesmat, Shahd Alkhazna et al. · Critical reviews in oncology... · 0 citations