TRANQUIL attenuates autoimmune demyelination and suppresses neuroinflammatory signaling in experimental autoimmune encephalomyelitis.
Neuroinflammation driven by autoreactive T cells and activated glial populations underlies the pathogenesis of multiple sclerosis (MS), yet current immunomodulatory therapies rarely restore durable immune tolerance and often cause broad immunosuppression. We previously engineered an attenuated Brucella melitensis ΔvjbR...