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Review Open access Sep 2026

Decoding the spatial logic of immune evasion in hepatocellular carcinoma: from single-cell profiling to spatial omics

Hepatocellular carcinoma remains difficult to treat because immune resistance is organized not only by malignant cell states but also by the spatial architecture of the tumor microenvironment. Single-cell RNA sequencing has clarified cellular heterogeneity in liver cancer, yet tissue dissociation removes the positional...

Nai-Te Xi, Shan Gao, Chao-Liu Dai · 0 citations

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