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Author

Shan Jiang

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Open access Sep 2026

The transcription factor THAP11 is a general regulator of early embryonic polarization

During mouse embryogenesis, three sequential waves of cell polarization occur in the 8-cell-morula trophectoderm (TE), E3.5-E4.5 primitive endoderm (PrE), and E4.5-E5.5 epiblast (Epi), driving cell fate determination and morphogenic events that lay the foundation for embryonic development. However, it is not clear whet...

Qian-Ying Yang, Shan Jiang, Bo-Yan Wang et al. · 0 citations
Open access Aug 2026

Rescue schizophrenia-related phenotypes caused by Setd1a deficiency by histone demethylase inhibitors

This work provides a mechanistic link between high-penetrance SETD1A variants and region-specific brain dysfunction, establishing a framework for connecting rare loss-of-function variation in chromatin regulators to multidimensional neuropsychiatric phenotypes.

Yiqiong Liu, Guoguang Xie, Shan Jiang et al. · 0 citations

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