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Author

Shan-Lin Chen

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Open access Sep 2026

Generation and application of human pluripotent stem cells derived peri-nervoids

Autologous nerve grafts remain the gold standard for peripheral nerve repair, but donor scarcity, donor-site morbidity and incomplete functional recovery limit their use. Schwann cells (SCs) drive autograft-mediated regeneration, yet their limited availability and expansion impede SC-based therapies. Here, we generated...

Yan-Jun Guan, Rui-Chao He, Zi-Yue Xiang et al. · 0 citations
Aug 2026

PIK3CA in-frame deletion-activated PI3K/AKT signaling pathway drives macrodactyly.

The role of the PI3K/AKT pathway in the PIK3CA-related overgrowth is clarified, with one pediatric patient carrying a novel mosaic de novo in-frame deletion mutation in the PIK3CA gene identified.

Jing-Heng Wu, Shan-Lin Chen, Yun-Hao Xue et al. · 0 citations

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