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Shan-Shan Gu

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Open access Sep 2026

Leptin attenuates heat stress-induced mitoxyperilysis in porcine Sertoli cells by suppressing the mtDNA-cGAS-STING axis

Mammalian spermatogenesis is highly temperature-sensitive and relies critically on the protective function of Sertoli cells. Although heat stress is known to affect Sertoli cell fate, it remains unclear whether it triggers mitoxyperilysis and by what mechanism. Leptin is a multifunctional hormone that regulates energy...

Ming Guo, Jin-Yang Zhang, Shan-Shan Gu et al. · 0 citations

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