Author

Shane Stoeber

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Open access Aug 2026

Cohesin facilitates nucleosome invasion by transcription factors

Nucleosomes present a major barrier to transcription factor (TF) binding. However, a subgroup of TFs known as pioneer factors (PFs) can recognize motifs covered by nucleosomes and initiate chromatin opening. PFs also bind nucleosomal substrates with high affinity in vitro, which may facilitate their nucleosome invasion...

Shane Stoeber, Hengye Chen, Ruo-Wen Chen et al. · Science Advances · 0 citations

Open access Sep 2026

ATAC-seq and MNase-seq Detect Distinct Modes of Chromatin Accessibility

Chromatin accessibility shapes the ability of transcription factors (TFs) and the transcriptional machinery to engage genomic DNA and therefore plays a central role in gene regulation. Two widely used approaches for profiling chromatin accessibility are micrococcal nuclease (MNase)-seq and assay for transposase-accessi...

Shane Stoeber, M. Godin, Lu Bai · bioRxiv · 0 citations