Background Vericiguat, a novel soluble guanylate cyclase (sGC) stimulator, is indicated for high-risk worsening heart failure (HF). However, its real-world reporting profile when added to contemporary quadruple guideline-directed medical therapy (GDMT)—effectively creating a “quintuple” regimen—remains largely unexplor...
Da-Qiu Chen, Y. Wu, Zi-Xun Wang et al.· Frontiers in Cardiovascular...· 0 citations
The association between TyG-BMI and all-cause mortality differed between Chinese and US middle-aged and older adults, and TyG-BMI provided little or no incremental prognostic discrimination beyond BMI alone, which supports cautious, population-specific interpretation of TyG-BMI.
Current evidence linking gut-derived metabolites to myocardial mitochondrial homeostasis in heart failure is summarized, with emphasis on energy metabolic remodeling, oxidative stress, inflammation, mitochondrial quality control, cell death, and fibrotic remodeling.
Da-Qiu Chen, Ming-Xuan Su, Zhan-Xiong Xie et al.· Frontiers in Cardiovascular...· 0 citations
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