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Author

Shang Mu

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#artificial intelligence May 2026

A Multimodal 3D Foundation Model for Light Sheet Fluorescence Microscopy Enables Few-Shot Segmentation, Classification, and Deblurring

This work introduces a 3D foundation model for LSM data, pretrained on a large curated collection of 3D images spanning multiple organisms, stains, and imaging protocols, and learns transferable volumetric representations by jointly optimizing for masked reconstruction and image-text alignment.

Adina Scheinfeld, Hao-Tan Zhang, Shang Mu et al. · 1 citation

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