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Sep 2026

A Honeybee-Safer Pyrazolyl Pyrido[1,2- a ]pyrimidine Mesoionic Targeting Fall Armyworm nAChR α1/β2 Subunits

Spodoptera frugiperda is a highly destructive pest with widespread resistance to conventional insecticides. Mesoionic chemicals are promising for insecticide discovery, yet lepidopteran-active examples remain limited and many raise pollinator-safety concerns. Here, we report a series of pyrazole-decorated mesoionic p...

Rui-Lan Wang, Shang Wu, Huan Wu et al. · 0 citations
Aug 2026

Carbamate-Modified Pyrido[1,2-a]pyrimidinones: Design and Synthesis of Insecticides with High Efficacy and Low Bee Toxicity.

A set of new pyrido[1,2-a]pyrimidinone derivatives bearing a carbamate moiety attached via a methylene spacer at the 2-position is described, offering a new molecular template for the development of highly selective insecticides.

Qing-Qing Ma, Shang Wu, Luo-Man Zhang et al. · 0 citations

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