Open access
Aug 2026
Virus-induced deconjugation of ISG15 dysregulates innate immunity and cellular metabolism.
Genetically ablated the deISGylating activity of the SARS-CoV-2-encoded papain-like protease (PLpro) and found that loss of deISGylation boosted innate immune activation, attenuated viral replication, and promoted viral clearance in human cells and mice.
Jun-Ji Zhu, Guan-Qun Liu, Jie-Lin Xu et al.
· Immunity · 1 citation