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It is shown that GSDMA deficiency increases viral loads but reduces inflammation, tissue damage, and mortality upon infection, suggesting that disease severity is driven more by inflammation than by viral load.
It is shown that canonical sgRNA formation is associated with same-direction RNA-RNA interactions, and this finding highlights a potential link between non-canonical sgRNAs, genomic plasticity, and immune modulation, which may have implications for coronavirus adaptation.
The structure of PEDV HNXX-strain spike domain B (S1B) is determined and a strain-specific vulnerable site on the PEDV S-trimer is identified, providing insight into how cell-surface membrane fusion activity may influence viral entry pathway selection and antibody neutralization efficacy.
Porcine reproductive and respiratory syndrome virus (PRRSV) is a significant pathogen in swine, causing substantial economic losses globally. The host acute-phase response to PRRSV infection and its role in antiviral defense remain poorly understood. In this study, we identify serum amyloid A2 (SAA2) as a key acute-pha...
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