Author

Shao-Kai Wang

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Open access Sep 2026

scMustree: a multi-scale functional hierarchy for single-cell transcriptomic analysis

Abstract Motivation Resolving cellular heterogeneity requires methods that capture both discrete cell types and their functional relationships. Existing single-cell clustering approaches often produce flat partitions, limiting their ability to reveal rare cell states and continuous biological transitions. Here, we intr...

Yun-Pei Xu, Shao-Kai Wang, Li-Qing Ding et al. · Bioinformatics · 0 citations

Open access Aug 2026

SIMLINK enables accurate variant pathogenicity prediction through modeling the gene-variant-feature association structure

Abstract Motivation Predicting variant pathogenicity is crucial for clinical genetics. Existing approaches face two primary limitations. First, biologically, data for pathogenicity prediction often lacks explicit modeling of the gene-variant-feature association structure. A single gene can harbor multiple variants, and...

Hong-Dong Li, Chen-Lu Wang, Dongfang Yan et al. · Bioinformatics · 0 citations