The molecular functions of the CDK9/positive transcription elongation factor b (P-TEFb) axis, its role in super-enhancer-driven oncogenic programs, and the mechanisms by which CDK9 inhibition promotes apoptosis, epigenetic derepression, and tumor microenvironment remodeling are summarized.
Ti-Yao Liu, Zhongran Liu, Wen-Jing Wei et al.· Expert opinion on therapeuti...· 0 citations
A Parallel Mamba Dual-U Network that adopts a cascaded dual U-Net encoder-decoder for two-stage “coarse-to-fine” segmentation refinement and outperforms state-of-the-art methods on most core metrics, verifying its effectiveness and robustness for complex medical image segmentation.
Shao-Qiang Wang, Linhao Zhang, Guiling Shi et al.· PLoS ONE· 0 citations
High-order dynamic disentangled framework for predicting ncRNA-drug resistance associations is proposed, suggesting that HDBI provides an effective and interpretable framework for prioritizing ncRNA-mediated drug resistance associations and guiding downstream mechanistic investigation.
Tiyao Liu, Shu-Dong Wang, Baoming Feng et al.· Journal of Chemical Informat...· 0 citations
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