Brain O-GlcNAcylation in Neurodegenerative Diseases: Context-Dependent Mechanisms and Precision Therapeutic Translation
Highlights What are the main findings? O-GlcNAcylation exerts context-dependent effects in neurodegenerative diseases rather than being uniformly protective or detrimental. We propose a state-resolved framework integrating disease stage, cell type, subcellular localization, substrate specificity, and therapeutic interv...