Author

Shao-Wu Xiao

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Open access Aug 2026

Inhibition of Calpain-1 ameliorates doxorubicin-induced cardiotoxicity by suppression of p53-mediated ferroptosis.

It is suggested that Calpain-1 exacerbates DIC by stabilizing p53 to initiate p53-dependent cardiomyocyte ferroptosis, offering a novel therapeutic target and theoretical basis for DIC intervention.

Zhuo Zhang, Xin-Bin Zheng, Dabao Xiao et al. · Toxicology and Applied Pharm... · 0 citations

Aug 2026

Study on the potential role of KIF23 in doxorubicin-induced cardiomyopathy through multi-omics integration and AI-based screening.

This study identified KIF23 as a core gene associated with DIC and suggested that it may be involved in immune microenvironment remodeling and macrophage-related pathological processes, providing new insights into the molecular mechanisms of DIC and potential therapeutic targets.

Dabao Xiao, Zhuo Zhang, Xin Xiao et al. · Computational biology and ch... · 0 citations