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Author

Shaoxuan Zhang

2 papers indexed here

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Open access Sep 2026

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

Modulating autophagic processes has shown promise as a treatment for pulmonary fibrosis (PF) with recent studies identifying transient receptor potential mucolipin‐1 (TRPML1), a lysosomal ion channel, as a novel regulator involved in PF. However, the mechanism by which TRPML1 modulates autophagy in the context of PF re...

Jia-Tong Yao, Xiao-Ting Kang, Lu-Lu Meng et al. · 0 citations
Aug 2026

TMEM175 deficiency impairs autophagic degradation and alleviates mitochondrial oxidative damage in cardiomyocytes through AMPK activation.

Findings reveal a dual role for TMEM175: it maintains lysosomal-mitochondrial communication under basal conditions, yet its inhibition protects against oxidative stress primarily through AMPK activation.

Qing-Liu Li, Nan Hu, Li-Mei Zhao et al. · 0 citations

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