Structural insights and regulatory mechanisms of endogenous modulation of TRPV2 as a potential drug target.
The transient receptor potential vanilloid 2 (TRPV2) channel is a Ca2+-permeable non-selective cation channel widely expressed in immune cells, cardiomyocytes, neurons, and various cancers. It participates in diverse physiological and pathological processes, including neuronal differentiation, mechanosensation, immune...