Deletion of the c-di-GMP Phosphodiesterase BpdB Attenuates Brucella melitensis Virulence by Enhancing Oxidative Stress Sensitivity, Partially via the Host STING Signaling Pathway
It is demonstrated that BpdB contributes to B. melitensis virulence by enhancing oxidative stress resistance and dampening STING-dependent host responses, providing new insights into c-di-GMP-mediated host–pathogen interactions.