Chitosan-Coated PLGA Nanoparticles for Sustained Delivery of Epigallocatechin Gallate and Differential Cytotoxicity in HepG2 and HepaRG Cells
Introduction: Epigallocatechin-3-gallate (EGCG) is a green-tea catechin with well-documented antiproliferative activity, but its short half-life and poor stability in physiological media limit its application. This study aimed to develop chitosan-coated poly(lactic-co-glycolic acid) (PLGA) core-shell nanoparticle carri...