Preprint
Sep 2026
tteICE: An R Package for Estimating Treatment Effects on Time-to-Event Outcomes with Intercurrent Events in Two-Arm Trials
Evaluating treatment effects in clinical trials with time-to-event outcomes is complicated by intercurrent events (ICEs), e.g., treatment discontinuation or competing events. While the ICH E9 (R1) addendum outlines five strategies to address these challenges, accessible software implementing these methods is limited. T...
Yuhao Deng, Yi Zhou, Yi Wang et al.
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