Nano-Carriers in Biofilm-Associated Infections: Clinical Challenges, Regulatory Hurdles, and Translational Perspectives.
Biofilms are structured communities of microorganisms encapsulated by an Extracellular Polymeric Substance (EPS) matrix, which plays a crucial role in recurrent and chronic infections caused by implanted medical devices. The natural resistance of biofilms to antimicrobials and the difficulty in diagnosing them pose a c...