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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Shawn E Vinogradsky

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Open access Jul 2026

Two Mechanisms One Molecule: Developing a ‘Truly’ Bifunctional Degrader Targeting Rpn13 and CRBN

Truly-4 is the first noncovalent small molecule shown to degrade full-length Rpn13, a target previously approached using covalent or domain-restricted strategies, and establishes a generalizable framework for engineering bifunctional degraders that program the proteasome to execute parallel degradation mechanisms and h...

Cody A. Loy, Shawn E Vinogradsky, Darci J. Trader · 0 citations

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