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Prognostic and Predictive Effect of Age in Molecularly Defined Lower-Grade Gliomas.
PURPOSE Age ≥40 years is regarded as a high-risk feature and an indication for adjuvant chemoradiotherapy for patients with lower-grade glioma in clinical practice guidelines. It is unclear whether age remains a relevant prognostic factor for contemporary definitions of lower-grade gliomas in the molecular era. METHO...
Autism mutations rewire protein interaction networks to drive neurodevelopmental pathology.
Overall, these findings link genetic variation to protein networks and convergent neurodevelopmental dysfunction in ASD.