Jul 2026
BCMA-CAR Natural Killer Cells Suppress Myeloma in Bone Marrow but Allow Emergence of Extramedullary Disease 2266680
This study showcases α-BCMA-CAR-IL15 NK cell therapy as a potent anti-MM therapeutic, achieving sustained MM elimination from the bone marrow and greatly extending survival in a MM-xenograft model, however, α-BCMA-CAR-IL15 NK cells appeared ineffective at eliminating extramedullary disease.
Seung-Hwan Lee, Shelby Kaczmarek, Safa Ghaziasgar et al.
· Journal of Immunology · 0 citations