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Oct 2026

PET-based evaluation of short-term amyloid-β clearance and predictive factors in real-world Alzheimer's disease patients treated with lecanemab.

BackgroundAlzheimer's disease (AD) is a common progressive neurodegenerative disorder. Lecanemab, an anti-amyloid-β (Aβ) monoclonal antibody, is approved for AD treatment, but real-world efficacy and optimal PET application strategies remain incompletely defined.ObjectiveTo investigate lecanemab's Aβ clearance efficacy...

Z. Qiao, Xiao-Bin Zhao, Gui-Hong Wang et al. · 0 citations
Sep 2026

First-In-Human PET Imaging of Synaptic Vesicle Glycoprotein 2A with [18F]BIBD-181: Automation, Biodistribution, Dosimetry, and Preliminary Application in Epilepsy

In pilot epilepsy patients, [18F]BIBD-181 positron emission tomography results revealed focal SV2A reductions that were confined to the epileptogenic lesions, suggesting that SV2A imaging may offer more precise lesion delineation, particularly when [18F]FDG abnormalities extend beyond the true epileptogenic zone.

Z. Qiao, Shen Li, Yong-Zhong Zhang et al. · 0 citations

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